Will Manidis is a New York-based entrepreneur and investor. He co-founded ScienceIO, a healthcare AI company that was acquired by a large EMR provider. A 2019 Thiel Fellow and former managing partner at Dorm Room Fund, he is an active early-stage investor and writes on technology on his Substack, Minutes.
Will Manidis is a New York-based entrepreneur and investor. He co-founded ScienceIO, a healthcare AI company that was acquired by a large EMR provider. A 2019 Thiel Fellow and former managing partner at Dorm Room Fund, he is an active early-stage investor and writes on technology on his Substack, Minutes.
In Episode 479 of Hidden Forces, Demetri Kofinas speaks with Will Manidis, co-founder of healthcare AI company ScienceIO, 2019 Thiel Fellow, and early-stage investor, about the collapse of secular institutional legitimacy, the reassertion of divine faith and political violence as organizing forces in modern life, and what the concentration of AI-generated wealth means for the social contract, labor, and the future of economic participation.
The first hour traces Manidis’s background — his early upbringing as a Quaker and his experience building and selling a successful healthcare AI and data science company — before turning to the theological arguments animating his writings on technology and the innovation cycle. He contends that the secular institutions Western societies have built and iterated upon since the early twentieth century have exhausted their capacity to provide order and meaning, and that we are entering a period in which ancient forces of divine faith and savage violence are reasserting themselves. They discuss the collapse of state legitimacy, the competition over people and capital amid eroding institutional trust, the renewed interest in Christian theology, and the rise of a new political coalition spanning anti-war progressives, tech entrepreneurs, libertarians, and the religious right.
The second hour turns to artificial intelligence and its consequences for the political economy, labor displacement, wealth disparity, terrorism, and the social contract. Manidis argues that AI wealth is rapidly concentrating among a narrow set of individuals and zip codes, foreclosing the broad economic participation that previous technological waves made possible. Drawing a parallel to the First and Second Industrial Revolutions — and the labor violence that preceded the New Deal — he contends that the new social contract emerging from this wave of technological innovation will not be negotiated peacefully, but will be accompanied by explosive acts of violence directed at infrastructure and people. They examine the vulnerability of data centers and the electric grid, the prospect of a new left-wing coalition of aggrieved white-collar workers, and the international implications of AI-driven job destruction across Southeast Asia and other economies that have benefited from decades of service-sector outsourcing. The conversation closes with a discussion of Manidis’s essay “Nobody Walks to Canterbury” and his concept of totemization — the idea that in a world of infinite digital supply, only those things capable of motivating genuine sacrifice and surrender of daily comfort will command real economic and monetary value.
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Will Manidis is a New York-based entrepreneur and investor. He co-founded ScienceIO, a healthcare AI company that was acquired by a large EMR provider. A 2019 Thiel Fellow and former managing partner at Dorm Room Fund, he is an active early-stage investor and writes on technology on his Substack, Minutes.
Demetri Kofinas is a media entrepreneur and financial analyst whose mission is to help uncover the hidden forces and pivotal patterns shaping our lives. His contrarian perspective and critical-thinking approach has helped hundreds of thousands of people make smarter, informed decisions. This same methodology has helped guide Demetri’s decision-making as an early-stage investor and as a creator of several innovative media properties and live events.
Demetri Kofinas is a media entrepreneur and financial analyst whose mission is to help uncover the hidden forces and pivotal patterns shaping our lives. His contrarian perspective and critical-thinking approach has helped hundreds of thousands of people make smarter, informed decisions. This same methodology has helped guide Demetri’s decision-making as an early-stage investor and as a creator of several innovative media properties and live events.
Demetri Kofinas is a media entrepreneur and financial analyst whose mission is to help uncover the hidden forces and pivotal patterns shaping our lives. His contrarian perspective and critical-thinking approach has helped hundreds of thousands of people make smarter, informed decisions. This same methodology has helped guide Demetri’s decision-making as an early-stage investor and as a creator of several innovative media properties and live events.
Demetri Kofinas is a media entrepreneur and financial analyst whose mission is to help uncover the hidden forces and pivotal patterns shaping our lives. His contrarian perspective and critical-thinking approach has helped hundreds of thousands of people make smarter, informed decisions. This same methodology has helped guide Demetri’s decision-making as an early-stage investor and as a creator of several innovative media properties and live events.
Demetri Kofinas is a media entrepreneur and financial analyst whose mission is to help uncover the hidden forces and pivotal patterns shaping our lives. His contrarian perspective and critical-thinking approach has helped hundreds of thousands of people make smarter, informed decisions. This same methodology has helped guide Demetri’s decision-making as an early-stage investor and as a creator of several innovative media properties and live events.
